PROTECT YOUR HEART, FUEL YOUR LIFE

In today’s fast-paced world, where cardiovascular risks abound and active living is a cherished goal, citrafit® emerges as the ultimate solution. Citrafit® combines citrus bioflavonoids extracted from citrus peel with nitrate rich amaranthus extract. This groundbreaking all natural, high-quality supplement ingredient not only safeguards your cardiovascular health, but also improves your blood flow and boosts energy to help you lead an active lifestyle.

Experience the perfect synergy of cardiovacular health and enhanced vitality, empowering you to lead a life brimming with energy and enthusiasm.

How CitraFit® Protects Your Heart

Cardiovascular diseases (CVDs) have collectively remained the leading causes of death worldwide. Cardiovascular Risk Factors (CVF) are conditions or behaviors that increase the likelihood of developing heart diseases and other cardiovascular disorders.

A meta-analysis of over 13 randomized controlled trials that included 705 individuals showed that supplementation with Citrus Bioflavonoids, the major active component in CitraFit®, had a significant effect on reducing cardiovascular risk factors like:

• Serum triglyceride (TG)
• Total cholesterol (TC)
• Low-density cholesterol (LDL)
• Systolic blood pressure (SBL)

CitraFit® helps minimize CVF by Protecting the Endothelium Health

The endothelium is a single layer of specialized cells lining the interior surface of blood vessels, including arteries, veins, and capillaries. It serves as a crucial interface between the bloodstream and the vessel walls, playing a vital role in regulating vascular tone, blood clotting, immune response, and the exchange of nutrients and waste products between the blood and surrounding tissues.

Improves flexibility of blood vessels

• Flow-Mediated Dilation (FMD) is a medical test used to assess the health of blood vessels and their ability to dilate or expand in response to increased blood flow. It is marker for good endotheli- al function.
• Patients with metabolic syndrome demonstrated remarkable enhancement in Flow-Mediated Dilation (FMD) after supplementing with citrus bioflavonoid hesperidin at a dosage of 500mg/day for 3 weeks, highlighting its efficacy in supporting healthy endothelial function.

Reduces Oxidative Stress

• Increased physical activity induces a higher oxygen demand, and could induce an increased formation of Reactive Oxygen Species (ROS) as a result of the increased mitochondrial activity. During long-term, high-intensity endurance exer cise, the continuous ROS production may exceed the capacity of the cellular defense system leading to endothelium dysfunction.
• Multiple in-vitro studies have show Citrus Bioflavonoids to reduce oxidative stress by:
  • Scavenging reactive oxygen species (ROS) and maintaining redox balance.
  • Inhibiting enzymes generating free radicals, curbing their production and oxidative damage.
  • Facilitating the body’s natural antioxidant defense system, mitigating oxidative stress.

Anti-Inflammatory Effects

• Exercise-induced inflammatory response is important to stimulate muscle adaptations. The acute inflammatory response following intense activity is characterized by increased levels of circu – latory and intramuscular inflammatory markers. The vascular system is important for the inflammatory response because of the transport of systemic immune cells to the site of inflammation. In vessels, acute and chronic inflammation could damage the arterial wall and lead to endothelial dysfunction
• In paients with myocardial infarction, supplementing with citrus bioflavonoid hesperidin at a dosage of 600mg/day for 4 weeks showed significant reduction in circulating concentrations of systemic inflammation markers like C-reactive protein (hs-CRP), serum amyloid A (SAA) protein, soluble E-selectin (sE-selectin), interleukin (IL)-6 and leptin.

How CitraFit® Fuels your Life

Adenosine triphosphate (ATP) is the “energy currency of life”

It is broken down in cells to generate energy for activity. Intramuscular stores of ATP can sustain only a short period of muscle activity.

Oxygen is essential for ATP generation

During exercise, ATP needs to be generated by anaerobic glycolysis and oxidative phosphoryla- tion. This process is critically dependent on the respiratory and cardiovascular systems to ensure an adequate oxygen supply.

Blood flow is the main regulator of oxygen supply

Skeletal muscle contains a dense capillary network that serves to deliver oxygen and nutrients and remove waste products from the skeletal muscle cells. The endothelium plays a major role in the regulation of blood flow to peripheral muscles and is crucial for muscle perfusion.

Nitric Oxide helps boost Blood Flow

One of the ways endothelium regulated blood flow is by release of Nitric Oxide (NO), a molecule that plays a key role in vasodilation, the widening of blood vessels and leads to an increase in blood flow.

The Citrus Bioflavonoids in CitraFit acutely stimulates phosphorylation of Akt, AMP kinase (AMPK), and eNOS to mediate NO production in vascular endothelial cell. The Nitrate Rich Amarnthus Extract provides an extra boost of NO. Amaranthus is not only rich in nitrates, potassium (> 10% by weight) and antioxidant polyphenols (e.g. amaranthine), but also devoid of sugar and oxalates. and is superior to traditional nitrate rich foods like beetroot. The anti-oxidating properties of both ingredients further boosts NO production in our body.